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BACKGROUND:

HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1 and is produced by the digestion of its precursor Gag p55 by HIV-1 protease. This protein is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, it is used as a marker for observation of the development in the patient’s condition after treatment, as it indicated the amount of virus in the blood.

HIV-1 p24 protein is derived from a precursor polyprotein of HIV, p55, that is cleaved into shorter polypeptides namely p24 (core), p17 (matrix) and p7/p9 (nucleocapsid) proteins. The p24 protein is nonglycosylated and is of approximately 24 kDa size.

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