CD38 is a 45-kDa type II transmembrane glycoprotein that is found in various mammalian tissues and cell types and is capable of converting NAD+ into cyclic ADP-ribose (cADPR). The CD38 protein is expressed on activated B and T lymphocytes, NK cells, thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes, Ig-secreting plasma cells and erythrocytes. Furthermore, CD38 is widely used as a marker for B and T lymphocytes activation and differentiation. In addition, CD38 is expressed in myriad cell types of important organs including the liver, eye, spleen and brain. In addition to the role of its metabolites in mobilizing intracellular calcium, CD38 is believed to be playing important immunoregulatory roles including the induction of B and T cells proliferation, regulation of B-cell lymphopoiesis, apoptosis, protein phosphorylation, activation of certain kinases and cytokine release.

SOURCE:

CD38 Antibody is an affinity purified rabbit polyclonal antibody raised against a purified recombinant protein consisting of 258 amino acids from the carboxy terminus of human CD38.

RECONSTITUTION:

Reconstitute lyophilized antibody in 100 µl deionized H₂O (for CDA-322; 100 µg) or 1 mL deionized H2O (for CDA-791; 1 mg).

CONCENTRATION:

1 mg/mL in PBS after reconstitution.

PURITY & STERILITY:

CD38 Antibody has been shown to be > 95% pure by SDS-PAGE. CD38 Antibody is provided in a non-sterile solution. The product may be rendered sterile by 0.22 micron filtration. NOTE: THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN CLINICAL OR DIAGNOSTIC PROCEDURES.

SPECIFICITY:

CD38 Antibody reacts specifically with CD38 by Western blotting. Recommended dilution range for Western blot analysis: 1:1,000-1:10,000. Recommended starting dilution: 1:5,000.

STORAGE & HANDLING:

Store lyophilized sample at -20°C prior to reconstitution. Once the antibody has been reconstituted, store at 4°C. DO NOT FREEZE. Product is stable for one year from date of shipment.