Pigment epithelium-derived factor (PEDF) is a multipotent neurotrophic factor with potent activity both in the central nervous system and in the retina. To date, PEDF is the most potent angiogenic inhibitor found in the mammalian ocular compartment. Interestingly, recent studies have shown that decreased ocular levels of PEDF are associated with diabetic retinopathy and other neuroretinal dystrophic diseases. In addition, the neurotropic and anti-angiogenic properties of PEDF suggest this protein is of potential therapeutic value for control of neovascularization associated with tumor growth.
To facilitate research on this important member of the serpin protein superfamily, we have developed a sensitive PEDF ELISA using polyclonal antibodies that specifically detects native PEDF protein in human vitreous and other tissues.
Compared to other commercially-available PEDF ELISA kits, our PEDF ELISA is nearly 50-times more sensitive than the competitor's product. In fact, our assay starts at PEDF concentrations that are near the limit-of-detection for other PEDF ELISAs (see above). If you need to quantify PEDF levels in your studies, our PEDF ELISA kit is the best solution to consider!
| KIT FEATURES: | Limits of detection... range... 50X better than competitors' assay. |
| STORAGE & HANDLING: | Store at 4C. DO NOT FREEZE. Product is stable for at least six months from date of shipment. |
| BACKROUND: | Pigment epithelium-derived factor (PEDF) is a multipotent neurotrophic factor with potent activity both in the central nervous system and in the retina. To date, PEDF is the most potent angiogenic inhibitor found in the mammalian ocular compartment. Interestingly, recent studies have shown that decreased ocular levels of PEDF are associated with diabetic retinopathy and other neuroretinal dystrophic diseases. In addition, the neurotropic and anti-angiogenic properties of PEDF suggest this protein is of potential therapeutic value for control of neovascularization associated with tumor growth. To facilitate research on this important member of the serpin protein superfamily, we have developed a sensitive PEDF ELISA using polyclonal antibodies that specifically detects native PEDF protein in human vitreous and other tissues. Compared to other commercially-available PEDF ELISA kits, our PEDF ELISA is nearly 50-times more sensitive than the competitor's product. In fact, our assay starts at PEDF concentrations that are near the limit-of-detection for other PEDF ELISAs (see above). If you need to quantify PEDF levels in your studies, our PEDF ELISA kit is the best solution to consider! |
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